Mesotherapy (from Greek mesos, “middle”, and therapy from Greek therapeia, “to treat medically”) is a non-surgical cosmetic medicine treatment. Mesotherapy employs the technique of multiple injections of pharmaceutical and homeopathic medications, plant extracts, vitamins, and other ingredients into the subcutaneous fat. Mesotherapy injections are purported to target adipose fat cells, apparently by inducing rupture and cell death among adipocytes.

Mesotherapy is a cosmetic procedure promoted for cellulite treatment, liposculpting and body contouring. Physicians specializing in non-surgical cosmetic medicine or operating medical spas are the most common practitioners.